PhD fellowship in cancer research

PhD fellowship in cancer research

Oslo universitetssykehus HF

About the position

Dr. Håvard Lindholm is the principal investigator. The position will be located in the laboratory of Professor XXXX XXXX (jahnsenlab.org) at the Department of Pathology, Oslo University Hospital, Rikshospitalet.

This is a collaborative project between the XXXX XXXX team, the group of professor XXXX XXXX at Oslo University Hospital and the group of Professor XXXX XXXX at Princess Marget Cancer Centre in Toronto, Canada. All research groups are internationally leading experts in immunology, cancer, and bioinformatics.The project aims to explore how antiviral defense pathways can be harnessed to kill colorectal cancer cells. Colorectal cancer is the second most common form of cancer in Norway and novel therapies are needed to improve disease outcomes. In this project we will develop new method to measure double stranded RNA (dsRNA) and apply it to colorectal cancer samples. We will also explore mechanisms to induce dsRNA in cancer using intestinal organoids as a model and perform bioinformatic analysis on publicly available data. The work will be performed in a modern molecular biology lab with access to specialized equipment such as a P2 solo instrument which will be used to perform Oxford Nanopore Sequencing on site. We also have access to computational clusters which will be used for analysis.Antiviral defense pathways can be activated if dsRNA is expressed from our own genome. Normally, dsRNA is only present in a human cell infected with viruses and human cells have innate immune receptors that can recognize dsRNA. However, pathways dysregulated in cancer can lead to expression of repeated elements forming dsRNA. This would lead to the activation of antiviral defenses which can kill the cancer cell. Through the analysis in this project, we will hopefully understand when and where this dsRNA is expressed in cancer and how to target it for future cancer therapeutics. For more details see this review: Endogenous retroelements as alarms for disruptions to cellular homeostasis, Lindholm et al (2023), Trends in cancer, doi.org/10.1016/j.trecan.2022.09.001. Please get in touch if you don’t have access to the review.

The candidate will:

• Perform Oxford Nanopore sequencing of RNA samples.

• Do wet lab experiments exploring how to induce dsRNA in intestinal organoids.

• Create scripts to analyze the output of experiments.

• Perform bioinformatic analysis of publicly available data.

Wet lab experiments are an important part of the project, but they will mostly generate large datasets requiring bioinformatic analysis. Lack of experience with wet lab or bioinformatics can be accepted if the candidate has good experience in just one of the two. The principal investigator, and the rest of the team, have extensive experience in both molecular biology and bioinformatics and will provide necessary training.

The ideal candidate should meet the following criteria:

• Applicants must hold an MsC degree in biology, immunology, medicine, bioinformatics, computational biology, informatics or a related field.

• Experience in molecular biology techniques. Experience with library preparation, cell culture and growing organoids is a plus.

• Experience in bioinformatics. Knowledge of Python and analysis of sequencing data is a plus.

• Fluent oral and written communication skills in English.

Personal characteristics and skillsWe are looking for a highly motivated candidate who is interested in identifying and addressing important scientific problems and has a genuine passion for research. We also emphasize professional and personal qualities, as well as the ability to work well with others on our team. The ideal candidate will demonstrate initiative, accountability, and a systematic approach to their work, while also excelling in implementation and forming good collaborations with others.

The application must include:

• Application letter describing the applicant’s qualifications and motivation for the position.

• CV (summarizing education, positions, and academic work).

• MsC thesis.

• Copies of educational certificates and transcript of records.

• Letters of recommendation or names and contact details of 2-3 references (name, relation to candidate, e-mail and telephone number).

The application with attachments must be delivered in our electronic recruiting system, please follow the links “apply for this job”. Foreign applicants should attach an explanation of their university’s grading system. Please note that all documents should be in English (or a Scandinavian language).When assessing the applications, special emphasis will be placed on the documented, academic qualifications relevant to the project description, excellence in relevant project tasks and the candidate’s motivation and personal suitability.

FerdigheterAI-generert

• Analysere data

• Bioinformatikk

• Forskning i beregningsbiologi

• Laboratorieteknikker

• Python (dataprogrammering)

• Utføre laboratorieundersøkelser

Om arbeidsgiveren

Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.

• Sektor:Offentlig

• Sted:Sognsvannsveien 20,0372Oslo

• Bransje:Forskning, utdanning og vitenskap,Helse og omsorg,IT

• Stillingsfunksjon:Forskning/Stipendiat/Postdoktor,Helsepersonell,Utvikler (generell)

• Arbeidsspråk:Norsk, Engelsk

Nøkkelord

Oslo University Hospital, Phd, Science, Research, Analysis

Spørsmål om stillingen

• Kontaktperson:Håvard Takle Lindholm

• Stillingstittel:principal investigator

• Mobil:XXX-XXX-XXXX 70

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Firmaets beliggenhet

Sognsvannsveien 20,0372Oslo

Annonseinformasjon

• FINN-kode456432488

• Sist endret20.3.2026, 14:17

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